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| Pos. | Rider | Nat. | Team | Race time | Gap |
| 1 | Marquez Marc | ESP | Ducati Lenovo Team | 1'31''468 | |
| 2 | Bezzecchi Marco | ITA | Aprilia Racing | 1'31''528 | 0''060 |
| 3 | Fernandez Raul | ESP | Trackhouse Racing | 1'31''601 | 0''133 |
| 4 | Marquez Alex | ESP | Gresini Racing MotoGP | 1'31''648 | 0''180 |
| 5 | Zarco Johann | FRA | LCR Honda | 1'31''650 | 0''182 |
| 6 | Acosta Pedro | ESP | Red Bull KTM Factory Racing | 1'31''678 | 0''210 |
| 7 | Marini Luca | ITA | Honda HRC | 1'31''722 | 0''254 |
| 8 | Martin Jorge | ESP | Aprilia Racing | 1'31''735 | 0''267 |
| 9 | Quartararo Fabio | FRA | Monster Energy Yamaha MotoGP | 1'31''870 | 0''402 |
| 10 | Di Giannantonio Fabio | ITA | Pertamina Enduro VR46 | 1'31''977 | 0''509 |
| 11 | Espargaro Pol | ESP | Red Bull KTM Tech 3 | 1'32''005 | 0''537 |
| 12 | Aldeguer Fermin | ESP | Gresini Racing MotoGP | 1'31''127 | 0''341 |
| 13 | Morbidelli Franco | ITA | Pertamina Enduro VR46 | 1'32''171 | 0''703 |
| 14 | Razgatlioglu Toprak | TUR | Prima Pramac Racing | 1'32''205 | 0''737 |
| 15 | Bastianini Enea | ITA | Red Bull KTM Tech 3 | 1'32''221 | 0''753 |
| 16 | Binder Brad | ZAF | Red Bull KTM Factory Racing | 1'32''229 | 0''761 |
| 17 | Miller Jack | AUS | Prima Pramac Racing | 1'32''368 | 0''900 |
| 18 | Bagnaia Francesco | ITA | Ducati Lenovo Team | 1'32''461 | 0''993 |
| 19 | Mir Joan | ESP | Honda HRC | 1'32''621 | 1''153 |
| 20 | Moreira Diogo | BRA | LCR Honda | 1'32''638 | 1''170 |
| 21 | Rins Alex | ESP | Monster Energy Yamaha MotoGP | 1'33''322 | 1''854 |
11 September 15:00
12 September 10:10
12 September 10:50
12 September 11:15
12 September 15:00
13 September 14:00
Built in 1972, the Misano circuit was a venue for GP races in the 80s and 90s before dropping off the calendar for fourteen years. After a number of modifications to improve the infrastructure and a change in the track direction, Misano returned to the MotoGP calendar in 2007. As always for a ‘home’ round, the Ducati Team riders can count on the support of numerous fans present in the Ducati Grandstand.
Circuit data