Pramac Racing debuted in the 2002 MotoGP World Championship and, for two consecutive years, used the name of its supporting manufacturer, Honda.
From 2005 to 2007 the Pramac team and D'Antin MotoGP Team combined as one to form the Pramac d'Antin team, competing with Ducati bikes. Initially Italian Roberto Rolfo was riding but he then made way for Alex Hoffman, José Luis Cardoso and Alex Barros, who in 2007 would reach the podium at the Italian Grand Prix, bringing the team to an overall sixth place finish in the manufacturers' standings.
For the 2008 season the squad became the Alice Team. The riders for this season were Sylvain Guintoli and Toni Elias, who achieved two consecutive podiums at the Czech Republic and San Marino Grand Prix races, thus making the Alice Team the only satellite team to reach the podium twice during the championship.
In the 2009 championship, the team went back to being Pramac Racing, with its base in Casole d'Elsa in Italy; this was the year of the riders Mika Kallio, Niccolò Canepa and Aleix Espargarò.
Riding for the team in 2010 were Espargarò and Kallio once again, though the latter was replaced by Carlos Checa for the final two races.
The Pramac Racing Team decided to celebrate its first ten years in the MotoGP category, in 2011, with the return of Loris Capirossi, alongside young rider Randy De Puniet.
In 2012 the team decided to run just one bike ridden by Héctor Barberà, who achieved great success in various races. 2013 strengthened the team's link with Ducati, with the squad officially becoming a factory supported team.
For 2014, the Pramac Racing Team confirmed Italian talent Andrea Iannone and employed the championship's first Colombian rider,
Yonny Hernandez.
With Iannone's move to Ducati, Pramac Racing lines up in 2015 with Italian
Danilo Petrucci alongside already experienced Hernandez.
From the 2015 Mugello GP, the team has been known as Octo Pramac Racing thanks to an agreement with a new title sponsor. A fantastic second place for Danilo Petrucci at Silverstone is the best result scored in the 2015 season and the Octo Pramac Racing ends 6th in the team's final standings.
