1,103 kubik 90° V4 från Panigale V4 ersätts av 998 kubik Desmosedici Stradale R för att följa cylindervolymreglementet från World Super Bike Championship. Minskningen av cylindervolymen har åstadkommits genom att hålla borrningen samma vid 81 mm medans slaget har ändrats till 48,4 mm tack vare en ny smiddvevaxel i stål.

Den 998 kubiks 90° V4 ger ifrån sig 221 hästkrafter (162 kW) vid 15,250 varv med ett vrid på 112,4 Nm vid 11,500 (värde uppmätt vid EU typgodkännande). Varvstoppet är satt vid 16,000 varv (16,500 i sexans växel). Genom att byta ut standard avgassystemet mot en racing hel-system Ducati Performance från Akrapovič så förhöjs effekten till 234 hästkrafter (174 kW) vid 15,500 varv med ett nytt max vrid på 119 Nm vid 11,750 varv.

Desmocendici Stradale R har fått lättade interna komponenter som bidrar till att den kan nå 16,500 varv i sexans växel.

Desmosedici Stradale R motorn andas tack vare ovala spjällhus med aerodynamiska spjäll och en ökning i storlek med 4 mm (56 mm taotalt), ihopkopplade med insugstrattar som varierar i längd beroende på belastning.

Jämfört med Panigale V4 så är den nya vindrutan högre vilket förbättrar luftflödet över förarens hjälm och axlar.

The Panigale V4 R is provided with aerodynamic appendices derived from those used on the GP16, thus with a greater efficiency compared to those currently used in the MotoGP.

The aerodynamic appendices and the special design of the fairing increase the vertical load to the wheels (overall + 30 kg at 270 km/h). Increased load results in a reduction in the “floatation” of the front wheel at high speeds and of the wheelie tendency, and greater stability during braking, corner entry and cornering.

On the sides, the elegant air vents of the Panigale V4 are replaced by more efficient extractors, designed to manage the operating temperatures during the race of the more powerful engine that drives the competition Ducati Panigale V4 R. The extractors increase the speed at which the cooling air crosses the water and oil radiators by 6% and 16%, respectively.

The “Front Frame” of the Panigale V4 R stands out for the lightening on the machined side panels that allow to reach the stiffness target required by Ducati Corse and further reduce its weight.

The modifications to the chassis are completed by the possibility of adjusting the height of the rear swinging arm pivot to 4 positions in steps of 2 mm. The adjustable pivot increases the adjustment possibilities to more precisely adapt the bike to the riding style and the type of track.

Considering its special use, almost exclusively on track, the Panigale V4 R is not provided with the Öhlins event-based, semi-active suspensions of the V4 S, but features professional mechanical units of the Swedish company

The Panigale V4 R is equipped with the latest generation electronic package, the one of the Panigale V4, that manages all riding phases, based on the use of the 6-axis inertial platform by Bosch (6D IMU – Inertial Measurement Unit), suitably reviewed in the logic of intervention to better support the professional riders.

The new Panigale V4 R uses the same cutting-edge, high resolution 5" full-TFT colour display (186.59 PPI - 800xRGBx480) as the Panigale V4. Graphics have been revised to reflect the introduction of new functions and the higher engine rev 'red zone'.

The Panigale V4 R is provided with a lap timer integrated in the instrument panel, with evolved functions with respect to the one available for the Panigale V4.

The Pit Limiter makes its debut on the Panigale V4 R: once enabled, by pressing the proper key on the right-hand block, it self-limits the bike speed when riding in the pit lane. The speed limit can be changed through the specific menu from a minimum of 40 km/h to a maximum of 80 km/h.