The Panigale V2 frame consists of a compact, enhanced-strength die-cast aluminium monocoque structure that uses the Superquadro engine as a stressed member.
Attached directly to the cylinder heads, the monocoque frame protrudes forward to house the steering head bearings, contained in two aluminium bushes. In addition to working as a frame, the monocoque also acts as an air-box; it contains not just the air filter but also the throttle bodies and the fuel circuit, complete with injectors, and is sealed off by the steel fuel tank bottom.
The front-end geometry has 24° of rake and 95 mm of trail. At the rear, instead, the double-sided swingarm has been replaced with a sophisticated, fully die-cast aluminium single-sided swingarm. The bike has a 1,436 mm wheelbase and weight distribution is 52% at the front and 48% at the rear.